PIPELINE

OB002

OB002 is a preclinical monoclonal antibody program aimed at a biomarker-linked inflammatory axis in obesity-associated cardiovascular disease. We translate a disease-relevant signal into a targeted antibody approach—with epitope logic, functional endpoints, and a clinical path built in from day one.

Modality: mAbStage: PreclinicalFocus: Obesity-related cardiovascular disease
Teaser overview

OB002 targets a mechanistically implicated inflammatory mediator (LCN2) that tracks with obesity and cardiometabolic dysfunction. Our strategy is designed to modulate downstream remodeling and fibrosis signals—prioritizing functional impact and translation, not just binding.

Target biology
LCN2 inflammatory axis
Differentiation
Function-first epitope logic
Translation
Biomarker-aligned endpoints
Path to clinic
Humanization to IND package
Technology edge

OB002 is developed through an antibody workflow that couples epitope-aware design with mechanistic screening and disease-relevant functional readouts. Lead selection emphasizes biophysical quality and scale-up readiness to support IND execution.

Epitope-aware engineering
Mechanistic and functional screening
Humanization and CMC readiness
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Preclinical focus (high-level)
Mechanism
Inflammation + fibrosis pathway modulation
Function
Cardiac structure/function readouts
Translation
Biomarker-linked stratification & PD